Improving HCLS AI reasoning with open-source agent skills

AI agents built on foundation models (FMs) often misapply healthcare and life sciences (HCLS) decision frameworks, even when they’ve seen the guidelines in training and in the system prompt. Ask an agent to classify a TP53 missense variant using ACMG/AMP criteria. It will cite the correct framework but misapply evidence categories, skip population frequency thresholds, or hallucinate computational predictor scores. The model knows facts but lacks the structured reasoning procedures that domain practitioners interna